I came up with a solution I'm going to try for this.
Basically, i'm going to set up a server on my desktop, serving up many things - one of which is a PXE server
I'll then have my main work machines, two thinkpads as diskless clients, using their onboard SSD's as cache; and serving up a shared home directory to each machine. It seems that this is possible to do, coming from such things as http://wiki.ltsp.org/wiki/Concepts
I'll keep this updated as things change, but i'm planning on creating a small builld chain and config to generate the images for a specific type of device. I want to have the ability to do musl or glibc on boot on x86, or start up on a Pi, and this way it should be doable.