Last update is from 2017, this got to change!
To make the discussion more interesting, bump with any distribution that caught your attention, something you find innovative, niche, or out of the usual.

I'll add EasyOS to the list. It's got everything containerized, using its own custom container tech. The user runs as root. The package manager keeps an audit trail. It runs on a layered filesystem where the lowest is read-only and can be pluggable/upgradable/swapped.

Another impressive work is Talking Arch. It's Arch Linux but made in an accessible way for visually impaired persons. It's impressive the amount of work that went into the audio tutorials. Obviously, there are more "friendly" distros for visually impaired persons.