I use QWERTY, and my own language in custom layout. I tried to make my custom english layout as well, but it was such pain to use, after couple of months I totally forgot QWERTY, and couldn't do even basic typing in new VMs, games, other computers, shortcuts were confusing and uncomfortable. Living without QWERTY is monumental commitment. I think you have to have QWERTY in your muscle memory no matter what.
I also use a custom keyboard with modifiers as tap-hold-keys on my homerow. Using ANSI is less comfortable to me now, but not unusable. In the future I want to buy a regular 60% keyboard and will practice it once a week to keep it in memory, while giving more efficient english layout a second chance.